ارتباط هیرسوتیسم با میزان هورمون های جنسی

Background and Aim: Hirsutism is defined as the excessive growth of thick dark hair in locations where hair growth in women is usually minimal or absent. There are many causes for hirsutism; such as hormonal disorders (ovarian and adrenal diseases) and tumoral diseases. This study was conducted to determine the relationship between hirsutism and hormonal disorders and polycystic ovary syndrome (PCOS) among high school and college female students. Materials and Methods: This case-control study (35 cases and 35 control ones) was done to evaluate the relationship between hirsutism and hormonal disorders by measuring of sex hormones (testosterone and 17-α - hydroxy progesterone) and ultasonography of ovary. Data was analyzed through SPSS software, Chi- Square, logistic Regression analysis and t test at the level α=0.05. Results: Mean testosterone level in the case and control groups were 0.63± 0.33 ng/ml and 0.37±0.15 ng/ml respectively (P<0.05). 13 (37.1%) girls of case group and 4 (11.4%) of the control group had PCOS (P= 0.017, OR=4.6). The 17-α- hydroxy progesterone level was abnormal in 10 (28.6%) of the case group and 2 (5.7%) of the control group (P=0.02, OR= 6.6). Conclusion: According to the results there is a significant relationship between hirsutism and PCOS and adrenal disorders. A further investigation (clinical trials) is recommended.